Ben’s Peptide Stack for Restoration, Explosive Beneficial properties, & Ageless Vitality

September 17, 2024

Peptides—brief chains of amino acids which are the “constructing blocks” of proteins—might be extraordinarily efficient for concentrating on a single pathway or mechanism within the physique with nice precision. For instance, BPC-157 might help you get better quicker by quelling irritation, LL-37 can help a greater immune system and squash a bout of SIBO, giardia, or different intestine points, and Semax might be efficient as a potent nootropic or good drug equal for cognitive efficiency.

While you “stack” a number of peptides, nevertheless, and use them collectively in a multi-targeted method for a broader well being objective, their advantages can compound and turn into much more highly effective—typically serving to you expertise vital enchancment in a a lot shorter time frame.

However relating to which peptides work collectively, these you possibly can stack collectively safely and successfully, what doses to make use of, and the way typically to take every—issues can get somewhat complicated, to say the very least.

So on this article, I’m going to interrupt down the perfect peptide stacks (together with a number of that I’ve used efficiently myself) to focus on restoration, muscle acquire, fats loss, immunity, anti-aging, and extra.

I’ll additionally cowl advisable pointers for dosing every peptide, the frequency they need to be administered, whether or not peptides ought to be cycled on and off throughout the 12 months, the perfect time of day to take peptides, and way more!

Disclaimer: I’m not a health care provider and this isn’t to be taken, interpreted, or construed as medical recommendation. These are simply my private ideas and never a prescription, a prognosis, or any type of well being care in any respect. Please speak with a licensed medical skilled in case you’re interested by utilizing peptides. As of now, peptide remedy is taken into account “experimental” and lacks medical long-term analysis, so it is best to proceed at your individual threat. As well as, most of these items is banned by the World Anti-Doping Association (WADA), US Anti-Doping Association (USADA), and different worldwide governing our bodies of sport, so you shouldn’t use any of those compounds if you’re competing in any sanctioned sport. Additionally, please observe that the world of peptides is ever-evolving, and whereas I do attempt to maintain posted articles up to date, I can solely attest that this data is present as of September 2024. To test in case your peptide is authorized, go to globaldro.com, choose your nation, and have the title of the treatment available to see if it is banned in any athletic sport. 

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The Greatest Peptide Stacks for Your Well being Objectives

Now, earlier than I leap headfirst into the peptide stacking deep finish, let me give only one extra fast disclaimer (isn’t this authorized stuff enjoyable?!)…

…the dosing and frequency suggestions supplied under are merely common pointers.

Like several treatment or complement, peptide doses will change primarily based in your physique weight, dimension, and private well being standing. I like to recommend you begin on the decrease finish of a peptide dose and frequency to see the way you personally reply. Above all, it is best to comply with the directions out of your doctor or peptide producer.

I’d additionally extremely suggest that you just overview the detailed directions for reconstitution, storage, and administration supplied in this article before proceeding.

The “Get well Like Wolverine” Peptide Stack

One among my first severe forays into peptides was to heal an annoying, persistent, and fairly painful torn higher hamstring by utilizing what I name the “Recover Like Wolverine” stack.

And it labored—with fairly stunning velocity, no much less.

So you probably have irritating joint ache that will not go away, some type of muscle tear or sprain, or just need to improve your athletic restoration, this peptide stack beats the pants off your typical old-school “R.I.C.E.” protocol (rest, ice, compression, and elevation).

This potent restoration stack incorporates the next peptides: BPC-157, TB-500, ipamorelin, tesamorelin, and GHK-Cu.

BPC-157

Remoted from a bigger peptide often called “physique defending compound,” which is of course present in human gastric juice, BPC-157 has numerous benefits. These embody regenerative results resembling therapeutic muscular tissues, tendons, ligaments, bones, and pores and skin burns, in addition to rising blood movement by way of angiogenesis and providing highly effective anti-inflammatory properties. It can be taken orally—corporations resembling CanLab, Peptide Sciences, Limitless Life, and LVLUP Health have entry to oral variations of BPC-157 and a number of other of the opposite peptides listed under. 

The directions under embody pointers in case you’re taking oral tablets.

• Dosing Tips:
  • Injection: 250–350mcg 2x/day; OR
  • Injection: 500–700 mcg 1x/day; OR
  • Injection: 0.15mL of 2000mcg/mL answer daily for a 30-day cycle; OR
  • Oral: 500mcg capsules for a 30-day cycle
• Administration Route:
  • Subcutaneous injection for systemic therapeutic
  • Intramuscular injection for focused therapeutic
  • Orally for intestine therapeutic or comfort

Once more, you possibly can click here for dosing/reconstituting instructions. Sadly, as of January 1, 2022, the World Anti-Doping Agency listed BPC-157 as a prohibited substance, which means athletes topic to WADA laws are not allowed to make use of it in competitors or coaching, because it might end in disqualification or penalties.

TB-500 (Thymosin Beta-4)

TB-500 is a naturally produced peptide present in almost each a part of the human physique. It will increase the exercise of the muscle protein actin to advertise mobile progress and stimulate blood cell growth and has been proven to restore harm to the guts, pores and skin, tissue, ligaments, and different organs and supply ache aid. It’s in all probability the perfect peptide for muscle restore, nevertheless, TB-500 is banned by WADA and most different international sporting organizations each in-competition and out-of-competition.

But, in case you’re trying to promote wound repair and healing, it’s an unbelievable answer as a result of it acts on actin and myosin fibers in tendons, ligaments, and muscular tissues—which can be possible why this peptide is used as a preferred therapeutic and restoration technique within the horse-racing trade.

• Dosing Tips: Please observe that there are only a few pointers round dosing TB-500, so it’s greatest to comply with your practitioner or producer’s ideas. Nevertheless, here’s what I’ve used:
  • 5-2.5 mg, 2–3x/week; OR
  • 25mL of 3000mcg/mL answer each day for a 20-day cycle
• Administration Route:
  • Subcutaneous or intramuscular injection

Ipamorelin

Ipamorelin enhances restoration by way of the activation of human growth hormone (often called a “progress hormone secretagogue”), which is well-known to accelerate the healing process. In contrast to utilizing human progress hormone (HGH) instantly, nevertheless, ipamorelin—when used at appropriate doses—seems to be comparatively freed from unwanted side effects and won’t have an effect on or intrude along with your physique’s pure manufacturing of GH.

• Dosing Tips:
  • 100-500mcg 1-3x/day; OR
  • 10mL of 2000mcg/mL answer 1x/day, 5 days per week
• Administration Route:
• Timing Suggestions:
  • For greatest outcomes, it is strongly recommended to manage ipamorelin on the identical time each day and keep away from consuming meals and huge quantities of liquids not less than 1 hour earlier than and after.

Tesamorelin

Tesamorelin is like ipamorelin’s cousin; it promotes restoration by way of the identical GH pathways, serving as a “progress hormone stimulating hormone.” In different phrases, it binds to and stimulates progress hormone receptors with related efficiency as taking endogenous HGH—once more, with out the undesirable unwanted side effects.

• Dosing Tips:
  • 1mg 1–2x/day for five days per week for a 6–8 week cycle; OR
  • 5mL of 1mg/0.6mL answer 1x/day, 6 days per week for a 6–8 week cycle
• Administration Route:
• Timing Suggestions:
  • Earlier than mattress, take it not less than 90 minutes after consuming. Upon waking, take tesamorelin ideally earlier than train and consuming.

GHK-Cu

GHK-Cu is a naturally occurring copper complicated present in human plasma, saliva, and urine. It has many roles within the physique, together with selling restoration. It appears to act as an anti-inflammatory agent that controls oxidative harm post-tissue damage, in addition to signaling tissue remodeling and the generation of new, healthy tissue. Whereas GHK-Cu is greatest injected subcutaneously for restoration, it can be used topically/transdermally for different functions like pores and skin well being or hair regrowth—such because the case with Jay Campbell’s hair regrowth peptide formula.

• Dosing Tips:
  • 5mg 1x/day for a 5–10 day cycle; OR
  • 2mL of 10mg/mL answer 2x/day
• Administration Route:

Here’s a record of assets to find much more about these particular peptides:

• How To Use BPC-157: A Complete Dummies Guide To Healing The Body Like Wolverine.
• How To Build New Blood Vessels, Regenerate Muscle Tissue Fibers, Increase New Cell Growth & More With Something Called “TB-500.”
• Demystifying Growth Hormone-Releasing Peptides – Everything You Need To Know About GH, Ipamorelin, Tesamorelin & More!
• The Coolest, Craziest Peptides You’ve Never Heard Of (& Where To Get Them), Boosting Testosterone Without Drugs, The Newest Creatine Booster & More With LVLUP Health’s Kyal Van Der Leest
• How To Use Testosterone, Peptide Stacks That Will Blow Your Mind, The Truth About Getting Peptides On The Internet, & Much More With Jay Campbell.

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The “Lean and Imply” Peptide Stack (Muscle Acquire & Fats Loss)

As I’ve said many, many instances all through my profession, muscle mass just isn’t solely useful for staying robust and looking out good bare ;), it’s additionally important to sustaining a protracted and wholesome life.

So, in case you’re interested by getting greater, stronger, sexier, and quicker with age—along with lifting heavy issues, consuming sufficient protein, and avoiding inflammatory meals—peptides might be one other device in your toolkit that will help you concurrently construct muscle and burn fats.

(P.S.: This stack would work wonders when mixed with the train, way of life, and biohacking ideas lined in my article “Sexy Forever: How To Build Functional, Good-Looking Muscle For Life”). I notably like this one for morning fasted exercises.

This muscle acquire/fats loss stack contains the next peptides: IGF-1 LR3, ipamorelin, CJC-1295 (with out DAC), and tesamorelin.

IGF-1 LR3

There are mainly two mechanisms by which you’ll be able to improve muscle mass: hypertrophy (increase in muscle fiber size) or hyperplasia (increase in muscle fiber number).

IGF-1 LR3, which is basically the long-acting model of IGF-1, a potent anabolic peptide, works to increase muscle by stimulating hyperplasia.

• Dosing Tips:
  • 50–150mcg 1x/day for a 4-week cycle; OR
  • 4mL of 620mcg/mL answer 1x/day
• Administration Route:

Ipamorelin

As a result of it will increase growth hormone (GH) secretion, Ipamorelin can be a potent muscle-building peptide. GH has major effects on skeletal muscle and function, which is why it’s such a broadly used (and abused) sports activities efficiency drug.

• Dosing Tips:
  • 100–500mcg 1–3x/day for a 12-week cycle; OR
  • 10mL of 2000mcg/mL answer 1x/day, 5 days per week
• Administration Route:
• Timing Suggestions:
  • For muscle acquire/fats loss, I’ve personally seen the perfect outcomes utilizing ipamorelin earlier than bedtime on an empty abdomen.

CJC-1295 with out DAC (Modified GRF 1-29)

CJC-1295 features as a growth hormone-releasing hormone (GHRH) and increases IGF-1, which helps promote fats loss and elevated muscle protein synthesis.

For this stack, you’ll need to use CJC without DAC (drug affinity complicated), which is the shorter-acting model that extra intently mimics your physique’s pure progress hormone pulses.

• Dosing Tips:
  • 100mcg 1–3x/day for a 12-week cycle; OR
  • 10mL of 2000mcg/ml answer 1x/day, 5 nights per week
• Administration Route:
• Timing Suggestions:
  • Take CJC-1295 earlier than bedtime on an empty abdomen.

Tesamorelin

Tesamorelin’s mechanism of motion is similar to that of ipamorelin; it really works on progress hormone pathways and stimulates IGF-1, which triggers the manufacturing of muscle protein. It’s additionally been proven in massive medical trials to decrease visceral fat and reduce levels of triglyceride in the blood.

• Dosing Tips:
  • 1mg 1–2x/day for five days per week; OR
  • 5mL of 1mg/0.6mL answer 1x/day, 6 days per week
• Administration Route:
• Timing Suggestions:
  • For muscle acquire/fats loss, I’ve skilled the perfect outcomes by taking tesamorelin within the morning earlier than my fasted exercise. However it’s also possible to take it earlier than mattress, not less than 90 minutes after consuming.

Sources to study extra about these particular peptides:

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The “By no means Get Sick” Immunity Peptide Stack

Chances are you’ll be, like me, pulling out all of the stops to bolster your immune techniques nowadays.

Peptides can be incredibly effective for targeting the multi-faceted immune system—which incorporates many organs, cells, and signaling molecules—offering you with well-rounded help to fight no matter comes your manner.

(P.S.: This stack could be glorious for supporting your immune system when mixed with the opposite ideas in my article, “Three Little Known, Unconventional Antiviral Approaches For Boosting Your Immune System.”)

This immune-boosting stack contains the next peptides: TB-500, thymalin, and LL-37.

TB-500 (Thymosin Beta-4)

You don’t hear about it a lot, however the humble thymus gland is critical in developing your immune system. Thymosin beta-4, a peptide produced by this gland, performs a big position in regulating immunity and producing white blood cells, lymphocytes, T cells, B cells, and antibodies.

• Dosing Tips: There are only a few pointers round dosing TB-500, so it’s greatest to comply with your practitioner or producer’s ideas. Nevertheless, here’s what I’ve used:
  • 750mcg 1x/day, cycle for 3 months on/3 months off; OR
  • 3mg each different day, cycle for 3 months on/3 months off; OR
  • 25mL of 3000mcg/mL answer each day for a 20-day cycle
• Administration Route:

Thymalin

Thymalin is one more immune-boosting peptide produced by the thymus gland. It has immunomodulatory properties and performs a task in Th1 cytokine manufacturing (proinflammatory) and T cell (cell-mediated immunity) manufacturing and performance, each of that are important for antiviral protection.

• Dosing Tips:
  • 5–10mg 1x/day for 3-10 days, repeat each 6–12 months
• Administration Route:
  • Subcutaneous or intramuscular injection

LL-37

Analysis on this so-called “antimicrobial peptide” signifies that it additionally has antibiotic, antifungal, and antiviral properties. Thus, it might be extremely efficient for autoimmune points and intestine circumstances, including fungal and bacterial overgrowth.

Warning: If in case you have SIBO, the die-off and Jarisch-Herxheimer Reaction from LL-37 might be uncomfortable and will contain flu-like signs and diarrhea for as much as two weeks. After that, nevertheless, many individuals expertise the whole decision of SIBO signs and the elimination of bloating and fuel in response to carbohydrate consumption.

• Dosing Tips:
  • 100mcg 2x/day for 4–6 weeks
• Administration Route:

Sources to study extra about these particular peptides:

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The “Benjamin Button” Anti-Growing old & Longevity Peptide Stack

One among my private favourite methods to stack peptides is to “sluggish the getting old course of” and promote longevity—mainly turning me right into a real-life Benjamin Button.

All joking apart, there’s severely compelling analysis related to peptides and getting old. One idea, postulated by Professor Vladimir Khavinson, who is probably probably the most distinguished medical gerontology researcher in Russia, is that many of the woes of aging are due to the slow-bleed, continuous breakdown of proteins (bear in mind: proteins are made from peptide chains) in tissues and organs, which ends up in their eventual degradation and full-body getting old.

Nevertheless, if you replenish your peptide shops, they’re capable of restimulate protein synthesis in tissues. Which means as an alternative of experiencing protein degradation and organ breakdown with age, peptides allow you to really restore as you grow old. Fairly cool, proper?

This anti-aging stack contains the next peptides: epithalon, thymalin, GHK-Cu, MOTS-C, humanin, and FOXO4-DRI.

Epithalon

Epithalon (additionally confusingly known as epitalon, no “h”) is often known as the “major anti-aging peptide” as a result of it is among the only a few synthesized compounds that has been proven to directly activate the telomerase enzyme in humans. Telomerase renews and elongates telomeres, the caps on the ends of chromosomes that shield DNA from harm and cancer-causing errors. By activating telomerase, epithalon can reduce the shortening of telomeres, theoretically serving to you “age backward.”

I personally use the “Khavinson Protocol” for dosing epithalon (sure, the exact same aforementioned professor), which makes use of the precise dosage from a fifteen-year longevity examine in people that produced spectacular outcomes for controlling telomere shortening.

• Dosing Tips:
  • Khavinson Protocol: 5–10mg 3x/week for 3 weeks, cycle 1x/12 months; OR
  • 1mL of 3000mcg/mL answer, 1x/day
• Administration Route:
• Timing Suggestions:
  • Epithalon is greatest administered within the morning.

Thymalin

Thymalin is a peptide produced by the thymus and pineal gland. It has a constructive impact on virtually each system within the physique, together with the immune, cardiovascular, endocrine, and nervous systems.

This peptide is also believed to be able to prolong human life, which is why it’s an vital a part of this longevity stack. A 2003 study discovered that 2–3 years of remedy with thymalin was proven to cut back all-cause mortality for aged volunteers by an element of two!

• Dosing Tips:
  • 5–10mg 1x/day for 10 days, cycle 1–2x/12 months
• Administration Route:
  • Subcutaneous or intramuscular injection

GHK-Cu

GHK-Cu helps to maintain you younger and supple in numerous methods, together with selling wound healing and tissue regeneration (skin, hair follicles, stomach, bone tissue), increasing collagen and glycosaminoglycans, promoting blood vessel growth, possessing antioxidant and anti-inflammatory effects, and way more.

This peptide can be utilized topically/transdermally—resembling in skincare or hair regrowth formulas—or injected for systemic results.

• Dosing Tips:
  • Injection: 0.2mL of 100mg/mL, 1x/day
  • Transdermal: 1mL utilized 1x/day at night time
• Administration Route:
  • Subcutaneous injection for systemic results
  • Transdermal software for topical results (hair, pores and skin)

MOTS-c

Anti-aging researchers are now aware of the potent role metabolic health and mitochondria play in longevity. MOTS-c is one peptide that powerfully impacts each of those elements, serving as a potent metabolic regulator that may enhance autophagy, restore mitochondrial function, and improve insulin sensitivity.

It’s additionally been known as “exercise in a bottle” as a result of it could actually mimic a few of the results of train by activating the AMP-Ok pathway.

• Dosing Tips:
  • 10mg 1x/week for 10 weeks, 1x/12 months
• Administration Route:
• Timing Suggestions:
  • For added mitochondrial profit, administer MOTS-c proper earlier than endurance train, ideally within the morning.

Humanin

Humanin is one other mitochondrial peptide and has been proven to produce strong cytoprotective actions against a variety of stressors and age-related diseases, together with neurological problems, mitochondrial dysfunction, oxidative stress, hypoxic harm to the mind, and oxidized LDL ldl cholesterol.

Curiously, kids of centenarians (people that stay to be over 100 years outdated) have unusually high levels of humanin—a possible Fountain of Youth, maybe?

• Dosing Tips: There are only a few pointers round dosing humanin so it’s greatest to comply with your practitioner or producer’s ideas. Nevertheless, right here is the vary I’ve seen advisable (I’d not counsel exceeding 0.04mg/kg physique weight per day).
  • 1–1.0mg 1–2x/day for a 2–8 week cycle, 1x/12 months
• Administration Route:

FOXO4-DRI

FOXO4-DRI (D-retro inversion isoform) is a cell-penetrating peptide that’s been proven in mice to selectively cause destruction, or induce apoptosis, of senescent cells. Senescent cells cease multiplying however they don’t die off when they need to, which may result in extra irritation and accelerated getting old. Actually, cellular senescence has been tied to a number of age-related conditions like most cancers, diabetes, osteoporosis, Alzheimer’s, and dementia. So by selectively concentrating on these senescent cells, FOXO4 can help reduce the risk of diseases related to aging. Fairly cool!

• Dosing Tips:
  • 3mg each different day for six days, repeat 1–3x/12 months
• Administration Route:

Sources to study extra about these particular peptides:

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Abstract

So, there you’ve got it.

You are formally geared up with a few of the most potent peptide stacks on the market for recovering quicker, constructing muscle and shedding fats, having a rock-solid immune system, and residing a protracted, wholesome life.

To be trustworthy, I want I had this information once I was first tinkering with peptides a number of years in the past—it positive would have saved me an entire heck of a number of time, cash, and self-experimentation. Hopefully, you discover it as useful as I’d have again then!

In case you’re interested by any of the peptides talked about above (from trusted, respected sources) it’s also possible to try my Peptides Resources Page.

In abstract…

To “get better like Wolverine,” you possibly can stack:

If you wish to lose fats and acquire muscle, mix these peptides:

For reinforcing your immune system, strive stacking:

Lastly, to age gracefully and with a superb healthspan and lifespan, use this final anti-aging peptide stack:

Keep in mind: In case you want data on sourcing, administration, reconstitution, or different ideas for getting began, be sure to check out this article, as properly.

Moreover, if you wish to take your well being optimization to the following degree, think about diving deeper into the methods and insights shared above in my model new, not too long ago up to date, best-selling guide, Boundless (you can pre-order your copy now!). In Boundless, you may discover complete steerage on enhancing mitochondrial operate, optimizing circadian rhythms, and bettering sleep, amongst different superior strategies for reinforcing your well being and longevity. Whether or not you are interested by good medicine, peptides, or cutting-edge wellness practices, this guide covers all of it, offering actionable methods to raise your bodily and psychological well-being.

And, as all the time, I might love to listen to your ideas, questions, and suggestions, so be happy to drop me a line within the feedback part under, and I will make sure to reply!